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ea0037oc10.4 | Nuclear receptors and signalling | ECE2015

An autoregulatory loop of nuclear corepressor 1 expression controls hepatocarcinoma invasion, growth and metastasis

Martinez-Iglesias Olaia , Alonso-Merino Elvira , Velasco-Martin Juan P , Martin-Orozco Rosa M , Luengo Enrique , Garcia-Martin Rosa M , de Caceres Inmaculada Ibanez , Fernandez Agustin F , Fraga Mario , Gonzalez-Peramato Pilar , Varona Constantino , Palacios Jose , Regadera Javier , Aranda Ana

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. Genomic studies have shown the presence of inactivating mutations of the NCoR gene in human tumours and we have found that NCoR depletion with siRNA in hepatocarcinoma SK-hep1 cells enhances invasion, tumour growth and metastasis in nude mice, while expression of the thyroid hormone receptor β (TRβ) increases NCoR levels, repr...

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An autoregulatory loop of nuclear corepressor 1 expression controls hepatocarcinoma invasion, growth and metastasis

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